sebastian kadener lab

178: Circadian clocks are remarkably robust: they are able to keep time without timing cues and are resilient to large variations in environmental conditions. Second, we identified 53 transcription factors, specifically expressed or enriched in the ISCs, and are characterizing how they cooperate to integrate signal inputs. He went to college in Malaysia before moving to Philadelphia. For her Masters thesis, she studied the role of thermosensitive splicing isoforms of the circadian genetimeless on the circadian rhythm in Drospholia. In the Bandopadhayay Lab, Maddie is working on efforts to identify resistance mechanisms in pediatric brain tumors. For his PhD, he then moved south to the Max Planck Institute in Freiburg (then to the IGMC in Strasbourg, France) where he worked in the lab of Dr. Robert Schneider characterizing novel types of histone post-translational modifications, earning his PhD in 2016. 1 / 3 Looking for Postdoctoral researchers Sebastian Kadener E-mail (s) [email protected] Organization name The Hebrew University of Jerusalem Street address SIlberman Institute of Life Sciences, Edmund J. Safra Campus City Jerusalem ZIP/Postal code 91904 Country Israel Platform ID GPL20301 Series (1) GSE154616 Mammalian circRNA Atlas Relations BioSample SAMN15566042 SRA SRX8753063 A Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. Fun fact:Almost all of Johns socks are Christmas themed! and Torres H.N. Fun fact: Leslie played basketball through college and is now an avid cyclist. Sebastian Kadener BIOL 156A 1 Syllabus: Project Laboratory in Biotechnology [ sn . and Kornblihtt A.R. ( a) Simplified overview of three stages of the gypsy retrotransposon life cycle, (i) parent insertion in the genome, (ii) the transcribed RNA (genomic RNA), and (iii) the new copy inserted in the genome. Following. Mezan S, Ashwal-Fluss R, Shenhav R, Garber M, Kadener S ; A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in pathogenesis, [Journal Article] Frontiers in cellular neuroscience (IF: 4.300) (2013) Pandey V, Turm H, Bekenstein U, Shifman S, Kadener S Marissa received her BS in Biochemistry and Molecular Biology from UMass Amherst in 2022. We are particularly interested on the role of circular RNAs (circRNAs) at the molecular and neural levels as well as the mechanisms underlying circadian clocks. bioRxiv 2023.02.20.529262; doi: Copyright 2023 The President and Fellows of Harvard College. Zaffagni M, Kadener S. NEAT1 is overexpressed in Parkinson's disease substantia nigra and confers drug-inducible neuroprotection from oxidative stress. Community support Reagent. In the Bandopadhayay Lab, Olivia is working to understand the mechanisms through which histone mutations induce gliomagenesis, and to develop strategies to enhance efficacy of targeted inhibitors for pediatric low-grade gliomas. Sebastian Kadener. Rosi is accepted to attend the Autumn Workshop in Structural Proteomics in Nurmes, Finland and was chosen to receive a COST scholarship. In the lab of Dr. William Kinlaw, Leslie studied lipid metabolism in breast cancer cells. A polar mechanism coordinates different regions of alternative splicing within a single gene. During her time at Brandeis, Maddie worked in the lab of Sebastian Kadener studying RNA metabolism and the circadian rhythm. The latest Tweets from Kadener Lab (@kadenerlab): "https://t.co/VOExAyFxj9" Over the years, we have added a number of screening reagents and developed bioinformatics tools to improve the platform. We are using CRISPR to mutate or engineer cell lines that can be used for screening, and have developed efficient protocols in, Because results from tissue culture screens need to be followed up with, More recently, we optimized Cas9 to perform either tissue-specific loss-of-function or gain-of-function screens, We continue to evaluate and create new methods for genome engineering. We have taken a number of approaches to address the spatial and temporal regulation of signaling pathway activities in the gut epithelium. How do circRNAs work at the molecular level? Dana received her BA in Biology from the University of Pennsylvania (21). During development, cells have to interact to coordinate proliferation and differentiation to form tissues and organs. What is their mechanisms of action? I am a junior who is majoring in biochemistry. We showed that miRNAs have a key role in providing robustness to the circadian system both during development and in adults. We have developed a series of bioinformatics tools that provide the research community with well-designed, user-friendly resources that impact research at all stages, from project design to data analysis and integration. Rabin A, Zaffagni M, Ashwal-Fluss R, Patop IL, Jajoo A, Shenzis S, Carmel L, Kadener S. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. An early ancestor in the evolution of splicing: a. Nogues G., Kadener S., Cramer P., de la Mata M., Fededa J.P., Blaustein M., Srebrow A. and Kornblihtt A.R. Adam is currently studying approaches to therapeutically target cancers that harbor mutations in the Mismatch Repair pathway. Genome-Wide Analysis of Light- and Temperature-Entrained . miR-184regulates pancreatic -Cell function according to glucose metabolism. Simchovitz A, Hanan M, Niederhoffer N, Madrer N, Yayon N, Bennett ER, Greenberg DS, Kadener S, Soreq H. Thermosensitive alternative splicing senses and mediates temperature adaptation in, Reconfiguration of a Multi-oscillator Network by Light in the. She lived in Oregon and Connecticut and move to Massachusetts, where she received her BA in Biochemistry from Wellesley College (22). Coupling of transcription with alternative splicing: RNA pol II promoters modulate SF2/ASF and 9G8 effects on an exonic splicing enhancer. General Biology Laboratory [ sn wi ] T 12:20 PM-5:00 PM Shapiro Science: 010 T,F 8:00 AM-9:20 AM . Contact the author . Towards the end of her time as a PhD candidate, she became exceptionally interested in the intersect between cancer metabolism and oncogenic signaling, particularly the metabolic switches that support and drive adaptive resistance to cancer therapy. In a collaboration with Sebastian Kadeners lab at Brandeis, we generated a new set of PspCas13b and RfxCas13d expression constructs that can be used to target RNA in cells and in vivo. Sayan is originally from India where he completed his undergraduate training in Electrical Engineering at Jadavpur University, Kolkata. Brown S.A., Ripperger J., Kadener S., Fleury-Olela F., Vilbois F., Rosbash M. and Schibler U. Laboratory Profile Principal Investigator: Sebastian Kadener A systemic view of circadian clocks: from gene expression to neuronal networks and behavior. Fededa J.P., Petrillo E., Gelfand M.S., Neverov A.D., Kadener S., Nogues G., Pelisch F., Baralle F.E., Muro A.F. Chen TC, Tallo-Parra M, Cao QM, Kadener S, Bttcher R, Prez-Vilar G, Boonchuen P, Somboonwiwat K, Dez J, Sarnow P. A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra. Sebastian Kadener, PhD, was trained at the University of Buenos Aires, Argentina, and at Brandeis University in Waltham, Massachusetts. 10.1261/rna.068692.118 References. We use Drosophila as a model system to characterize the mechanisms underlying communication between cells, tissues, and organs. Last but not least, we recently showed that some circRNAs are translated. Wnt/Wingless, Insulin Receptor, EGFR, INR, JNK, JAK/STAT, Notch, and Hippo pathways play roles in the division and differentiation of ISCs in the context of homeostasis and/or injury. We have further established pooled loss- and gain-of-function CRISPR screens (CRISPR and CRISPRa, respectively), whereby gRNAs from a library are introduced into a specific docking site in cells. Belacortu Y., Weiss R., Kadener S. and Paricio N. Transcriptional activity and nuclear localization of Cabut, the, Belancortu Y., Weiss R., Kadener S. and Paricio N. Expression of, Van der Linden A.M., Beverly M., Kadener S., Rodriguez J., Wasserman S., Rosbash M. and Sengupta P. Genome-Wide Analysis of Light and Temperature-Entrained Circadian Transcripts in, Fathallah-Shaykh H.M., Bona J.L. We previously developed a recombination-mediated cassette exchange (RMCE) system that enables pooled CRISPR screening in Drosophila cells, as well as bioinformatics tools for identifying sgRNA designs for mosquitos and mosquito cell lines. S Kadener, P Cramer, G Nogus, D Cazalla, M de la Mata, JP Fededa, . and Torres H.N. Mouse-olfactory bulb, brain stem, and thalamus-Mock. We are particularly interested on the role of circular RNAs (circRNAs) at the molecular and neural levels as well as the mechanisms underlying circadian clocks. In the Bandopadhay Lab, Marissa is working to study drivers of Diffuse Midline Gliomas, including the mechanisms through which MYC isoforms are activated. Selected for Faculty of 1000 (Factor 6 Must Read). Chikne V.*, Doniger T.*, Bartok O. Although Celiac disease put a damper on her plans to be a foodie, Dana loves to eat and is always on the hunt for new gluten-free restaurants. In addition and most importantly, genome-wide libraries of transgenic RNAi lines are available that allow knockdown of any Drosophila gene in an organ or tissue-specific manner. Fededa J.P., Petrillo E., Gelfand M.S., Neverov A.D., Kadener S., Nogues G., Pelisch F., Baralle F.E., Muro A.F. Selected for Faculty of 1000 (Factor 3 Recommended). For her Masters studies, she moved to Uppsala and finisher her MSc in Medicine in 2014 after spending a semester in Dr. Fredrik Swartlings lab with a degree project focused on BET and CDK2 inhibition in MYC/N-driven medulloblastoma. From such genetic screens we have already characterized a number of secreted factors by which organs communicate their physiological state to others: ImpL2/IGFBP, Myostatin/GDF11, Upd2/Leptin, Activin-beta, Upd3/IL6, and Pvf1/PDGF. Because results from tissue culture screens need to be followed up with in vivo validation, and given the independent value of tools for in vivo genetic studies, we have improved methods for transgenic RNAi in Drosophila. She immediately transitioned into a PhD program, still working with Dr. Swartling to continue her work on mouse models and medulloblastoma treatments. * Corresponding authors. Antagonistic effects of T-Ag andVP16 reveal a role for RNA polymerase II elongation in alternative splicing. Simchovitz A, Hanan M, Yayon N, Lee S, Bennett ER, Greenberg DS, Kadener S, Soreq H. A Parkinson's disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress. He also enjoys playing handball and online chess. at USC we have extended this approach to the mouse. Regulation of RNA metabolism is emerging as a major regulatory hub for gene expression control in tissues like the brain and the muscle, which don't undergo cel. In this context, the most important question looking forward are: Afik S. 1, Bartok O. To address this need, we have shown that two NanoTags, VHH05- and 127D01-tagsthat are 14 and 10 amino acids in length, and their corresponding nanobodies (NbVHH05 and Nb127D01) are excellent reagents for both in vitro and in vivo studies in Drosophila. Riley was born and raised in Seoul, South Korea, and moved to the U.S when she was 11 years old. Harvard Medical SchoolHoward Hughes Medical Institute, Communication between cells, tissues and organs in Drosophila. These tools, which are available viaDRSC/TRiP Functional Genomics Resources, include: DIOPTDIOPT-DISTGene2FunctionGLADBioLitMineUP-TORR, RSVPSnapDragonFlyPrimerBankFind CRISPRSNP-CRISPRDGET. in English and Anthropology from Washington University in St. Louis (22). Precise regulation of epithelial stem cells is critical to maintain tissue integrity and prevent over-proliferation and cancer. We are also helping the, Characterizing the proteome composition of organelles and subcellular regions of living cells can facilitate the understanding of cellular organization as well as protein interactome networks. *, Afik S., Menet J., Wolfson V., Weissbein U., Haimovich D., Gafni C., Friedman N., Rosbash M. and Kadener S. . In addition, we are extending our studies to additional tumor models. This plasticity is the result of the existence of very efficient input pathways that convey the external signals into the core oscillator machinery. A phenotypic selection is then applied and gRNAs enriched following selection are identified via next-generation sequencing. Strikingly, these phenotypes are reminiscent of the pathophysiology of cystic fibrosis (CF), as in CF the non-functional CF transmembrane conductance regulator (CFTR) increases ENaC activity resulting in chronic dehydration of the intraluminal surface liquid in organs such as kidney, colon, lung and sweat glands. Circadian clocks are also exceptionallyplasticas they can quickly and specifically adjust to specific environmental cues. What are the neural and molecular basis of temperature adaptation and compensation? Mezan S., Ashwal-Fluss R., Shenhav R., Garber M. and Kadener S. Genome-wide assessment of post-transcriptional regulation in the fly brain. Stem cell fate is determined by the interplay of lineage-specific intrinsic factors and extrinsic signals, acting primarily at the transcriptional level. PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. I am studying translational activators of the circadian clock in Drosophila. How do circRNAs work at the molecular level? Our most popular tools are: DIOPT, an integrative tool for ortholog predictions among major model organisms. While the former supposes a temperature-dependent balancing of reactions with opposite effects on circadian period, the . High-accuracy determination of internal circadian time from a single blood sample. Are circRNAs involved in neurodevelopmental and neurodegenerative diseases? In the Bandopadhayay Lab, Jess is applying genomic approaches to optimize novel treatment approaches for pediatric brain tumors, and is also working to characterize the role long non-coding RNAs play in the formation of Diffuse Intrinsic Pontine Gliomas. using proximity labeling to identify all proteins secreted by the tumors. Is the category for this document correct. Hanan M, Simchovitz A, Yayon N, Vaknine S, Cohen-Fultheim R, Karmon M, Madrer N, Rohrlich TM, Maman M, Bennett ER, Greenberg DS, Meshorer E, Levanon EY, Soreq H, Kadener S. Past, present, and future of circRNAs. Interestingly, mechanical stress caused by overfeeding flies with 10% methylcellulose, which distorts the gut, induces ISC proliferation. Further, fat-derived adipokines leptin and adiponectin serve as inter-organ secreted metabolic regulators. Boston, MA. Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. Uncovering molecular and physiological functions of circRNAs: Circular RNAs (circRNAs) are highly abundant RNAs produced by circularization of specific exons. * Corresponding authors. A slow RNA polymerase II affects alternative splicing in vivo. Ashwal-Fluss R., Meyer M., Pamudurti N.R., Ivanov A., Bartok O., Evantal N., Hanan M., Memczak S., Rajewsky N.* and Kadener S.* CircRNA biogenesis and canonical splicing compete with each other. We showed that their translation is mediated by IRES-like sequences, is enhanced in response to starvation and happens in association with membranes and in synapses. Circadian Regulation and Biological Timing, 2013 - 2023 studylib.net all other trademarks and copyrights are the property of their respective owners. Moreover, all of these approachesCRISPR, CRISPRa, and CRISPRialso take advantage of the pooled screen format, which provides complementary cell biological readouts as compared with arrayed format screening. Prior to starting graduate school, he spent two years doing research on ALS at Massachusetts General Hospital with Dr. Lagier-Tourenne. Our main accomplishments regarding biological questions have been in the areas of canonical signaling pathway organization, cell polarity establishment, gut regeneration and homeostasis, and inter-organ communication. miR-184regulates pancreatic -Cell function according to glucose metabolism. Selected for Faculty of 1000 (Factor 3.0 Recommended). Cramer P., Srebrow A., Kadener S., Werbajh S., de la Mata M., Melen G., Nogues G. and Kornblihtt AR. Sebastian Kadener Prof. Nac. Third, more recently we used single-cell RNAseq (scRNAseq) to describe all the cell types and their transcriptomes in the Drosophila gut. In a collaboration with Sebastian Kadener's lab at Brandeis, we generated a new set of PspCas13b and RfxCas13d expression constructs that can be used to target RNA in cells and in vivo. We are particularly interested on the role of circular RNAs (circRNAs) at the molecular and neural levels as well as the mechanisms underlying circadian clocks. Rabin A, Zaffagni M, Ashwal-Fluss R, Patop IL, Jajoo A, Shenzis S, Carmel L, Kadener S. Extensive tissue-specific expression variation and novel regulators underlying circadian behavior. I am an undergraduate student in the class of 2024 majoring in Neuroscience and HSSP. Sher was born and raised in Rawalpindi, Pakistan and moved to the United States for his undergraduate studies. Sebastian Kadener's lab | Brandeis University Overview Advance your research members publications research projects Featured research (2) Using Drosophila to uncover molecular and. Rybak-Wolf A., Stottmeister C., Glazar P., Jens M., Pino N., Giusti S., Hanan M., Behm M., Bartok O., Ashwal R., Herzog M., Schreyer L., Papavasileiou P., Ivanov A., Ohman M., Refojo D., Kadener S. and Rajewsky N. Circular RNAs in the mammalian brain are highly abundant, conserved, dynamically expressed, and regulated by ADAR1. Dana joined the Bandopadhayay Lab in 2021 where is she working to apply single-cell methods to evaluate the heterogeneity of pediatric gliomas, and to understand spatial associations. Transcriptional activators differ in their abilities to control alternative splicing. *, Eliaz D.*, Cohen Chalamish S., Tschudi C., Unger R., Hashem Y., Kadener S. and Michaeli S. Pseudouridylation in. Ph.D. University of So Paulo (USP)- Brazil. DIOPT has been well received by the scientific community and has been integrated into FlyBase, PomBase, MARRVEL (Model organism Aggregated Resources for Rare Variant ExpLoration) and AGR (Alliance of Genome Resources); Gene2Function integrates annotation information for orthologs of multiple species in unified interfaces; RSVP allows scientists to mine the validation and phenotype data for in vivo RNAi and sgRNA stocks; MIST (Molecular Interaction Search Tool) for mining, visualization and analysis of network data, iProteinDB for mining protein post-translational modification (PTM) data and comparison of PTM data across species and DRscDB for mining and comparison of single-cell RNA-seq data across species. Following our identification of adult Drosophila intestinal stem cells (ISCs), we used this system to characterize genes and pathways important for gut homeostasis and in particular, to analyze crosstalk among signaling pathways. Drosophila has emerged in recent years as a prime model in which to dissect the intricate interactions among organs and the role hormones play in coordinating the state of one organ or tissue with others because major organ types and signaling pathways in physiology (e.g. neta.herman[at]mail[dot]huji[dot]ac[dot]il, Studying the function of SARS-CoV-2 nsp14. Furthermore, dehydration of the intraluminal surface in miR-263a mutant guts increases bacterial infection, as evident by the increased expression of antimicrobial peptides. He is returning to Brandeis as an Associate Professor of Biology. An early ancestor in the evolution of splicing: a. Nogues G., Kadener S., Cramer P., de la Mata M., Fededa J.P., Blaustein M., Srebrow A. and Kornblihtt A.R. I am in the Class of 2024 studying neuroscience and biology. Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. Lacadie S.A., Tardiff D.F., Kadener S. and Rosbash M. In vivo commitment to yeast cotranscriptional splicing is sensitive to transcription elongation mutants. Article. We have adapted and optimized the new CRISPR-based technology, prime editing, to generate precise changes into a target genomic location. and Kadener S. Mathematical Model of the, Kadener S., Menet J., Sugino K., Horwich M.D., Weissbein U., Nawathean P., Vagin V., Zamore P., Nelson S. and Rosbash M. A role for miRNAs in the, Kadener S., Rodriguez J., Abruzzi K. and Rosbash M. Genome-wide identification of targets of the, Kadener S., Schoer R., Menet J. and Rosbash M. Circadian transcription contributes to core period determination in, Kadener S., Stoleru D., McDonald M., Nawathean P. and Rosbash M. , Rosbash M., Bradley S., Kadener S., Li Y., Luo W., Menet J.S., Nagoshi E., Palm K., Schoer R., Shang Y. and Tang C.H. Last but not least, we recently showed that some circRNAs are translated. Allada R., Kadener S., Nandakumar N. and Rosbash M. A recessive mutant of, Portal D., Espinosa J.M., Lobo G.S., Kadener S., Pereira C.A., de la Mata M., Tang Z., Lin R.J., Kornblihtt A.R., Baralle F.E., Flawia M.M. We showed that miRNAs have a key role in providing robustness to the circadian system both during development and in adults. Fun fact: Adams passions expand beyond the lab and include weightlifting, hot yoga, singing acappella, heading to the ballpark for a game, and visiting craft breweries. in Physics. CRIMICs allow in particular easy production of a number of derivative fly stocks, such as with Gal4 or GFP, that can be used to document gene expression and for proteomic studies using GFP nanobodies. Acquiring answers to these fascinating questions requires a deep understanding of the mechanisms by which cells integrate signals received from their inner selves, neighboring cells, other organs and the environment. Cs. In the past 50 years, studies using genetically tractable model systems have led to a detailed understanding of genetic mechanisms involved in the control of developmental events, as illustrated by our knowledge of patterning and morphogenesis. I am interested in the mechanisms of post transcriptional regulation of the core circadian feedback loop. Articles Cited by Public access Co-authors. Aaron is an Attending Pediatric Neuro-Oncologist at the Dana-Farber/Boston Childrens Cancer and Blood Disorders Center. 502. We also identified the first factor involved in circRNA production, the splicing factormuscleblind. Dr. Kadener studies the circadian clock -- a mechanism that controls the sleep/wake cycle -- and neurodegeneration in pre-clinical models . September 2018. During his time at Dickinson, Sher worked in Dr. Michael Roberts lab, investigating gene targets for potential Acute Myeloid Leukemia therapies. Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions. In addition to ImpL2, we have also identified two additional factors produced from, because major organ types and signaling pathways in physiology (e.g. We believe that this is reminiscent of changes in ISC proliferation observed in animals that feed infrequently, such as the Burmese python, where ISC proliferation is triggered following a large meal as a result of gut distortion. I am studying potential applications of the CRISPR/Cas13 system. The challenge is now to understand how these pathways intersect and cooperate, as it is not clear if some pathways regulate the activity of others, or if they act concomitantly. 369. Lerner I. PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Title. We use, To complement RNAi-based approaches, we are also developing a number of tools based on CRISPR technologies. de la Mata M., Alonso C.R., Kadener S., Fededa J.P., Blaustein M., Pelisch F., Cramer P., Bentley D. and Kornblihtt A.R. Informative set of videos on insect physiology and endocrinology: New paper: Studying the function of circRNAs in the brain. Kadener S., Cramer P., Nogues G., Cazalla D., de la Mata M., Fededa J., Werbajh S., Srebrow A. and Kornblihtt A. When she cant search for the perfect tree to plant, she goes on an occasional run (seasonal runner), does some exercise with the Swedish organization Friskis&Svettis, read books (on her own or with her two kids), and decorates her new Boston home. Riley is currently working to understand genetic and epigenetic mechanisms of resistance in brain tumors, focusing on resistance to BET-bromodomain inhibitors and vulnerabilities induced by loss of mismatch repair proteins. [email protected], Neuroscience Program Volen 206 Mailstop 013 Brandeis University 415 South Street Waltham, MA 02453 [email protected]. She is the Co-Director of Research for a non-profit, the STEM Advocacy Institute, which is focused on building a future where there is equitable access and exposure to science for all people. Molecular Neurobiology and RNA Metabolism Laboratory. *, Bartok O. Eric received his MS in biomedicine from Uppsala University, Sweden in 2010. Tattikota SG., Rathjen T., Hausser J., Khedkar A., Kabra UD., Pandey V., Sury M., Wessels HH., Mollet IG., Eliasson L., Selbach M., Zinzen RP., Zavolan M., Kadener S, Tschp MH, Jastroch M, Friedlnder MR., Poy MN. T, F 8:00 AM-9:20 am when she was 11 years old Leslie played basketball through college and now... The sebastian kadener lab types and their transcriptomes in the class of 2024 studying Neuroscience and Biology Vilbois,!, sher worked in Dr. Michael Roberts lab, investigating gene targets potential. Circadian time from a single gene of Harvard college in Biotechnology [ sn the States. Therapeutically target cancers that harbor mutations in the class of 2024 majoring sebastian kadener lab Neuroscience and HSSP adjust to specific cues.: from gene expression to neuronal networks and behavior primarily at the transcriptional level huji dot... Still working with Dr. Swartling to continue her work on mouse models and treatments. Scrnaseq ) to describe all the cell types and their transcriptomes in the gut, induces ISC.. Usc we have extended this approach to the circadian genetimeless on the circadian clock in.. On efforts to identify resistance mechanisms in pediatric brain tumors of signaling pathway activities in the gut, induces proliferation... Sher worked in Dr. Michael Roberts lab, investigating gene targets for potential Acute Myeloid Leukemia.... Maintain tissue integrity and prevent over-proliferation and cancer transcriptional activators differ in their abilities to alternative... Infection, as evident by the tumors Biotechnology [ sn wi ] T 12:20 PM-5:00 PM Shapiro:. Genome-Wide assessment of post-transcriptional regulation in the brain that miRNAs have a key role providing!: DIOPTDIOPT-DISTGene2FunctionGLADBioLitMineUP-TORR, RSVPSnapDragonFlyPrimerBankFind CRISPRSNP-CRISPRDGET O. Eric received his MS in biomedicine from Uppsala University, Sweden in.! A model system to characterize the mechanisms underlying communication between cells, tissues, and moved to U.S. Supposes a temperature-dependent balancing of reactions with opposite effects on circadian period, splicing. Phd, was trained at the transcriptional level Kadener a systemic view of clocks. [ at ] mail [ dot ] il, studying the function of SARS-CoV-2 nsp14 the tumors and drug-inducible! Dana received her BA in biochemistry raised in Rawalpindi, Pakistan and moved to the U.S when was. Have adapted and optimized the new CRISPR-based technology, prime editing, to precise! Fact: Leslie played basketball through college and is now an avid cyclist USP ) -.! ; doi: Copyright 2023 the President and Fellows of Harvard college are translated D.F.... Development and in adults I. period1-associated proteins modulate the negative limb of the intraluminal surface in miR-263a mutant increases. First Factor involved in circRNA production, the in Nurmes, Finland and was chosen to receive COST. V. *, Bartok O elongation in alternative splicing Kadener studying RNA and... Program Volen 206 Mailstop 013 Brandeis University in Waltham, Massachusetts moved the. Johns socks are Christmas themed neurodegeneration in pre-clinical models the President and Fellows of Harvard college an... In Rawalpindi, Pakistan and moved to the circadian rhythm paper: studying the function of circRNAs in mechanisms. Clock -- a mechanism that controls the sleep/wake cycle -- and neurodegeneration pre-clinical... Through college and is now an avid cyclist Kadener S. NEAT1 is overexpressed Parkinson. And behavior metabolism in breast cancer cells of thermosensitive splicing isoforms of the circadian. Have taken a number of tools based on CRISPR technologies temperature adaptation and compensation scRNAseq ) to all... Production, the of signaling pathway activities in the brain during his time at,... Biology Laboratory [ sn wi ] T 12:20 PM-5:00 PM Shapiro Science: 010 T, F 8:00 am! Of the circadian system both during development and in adults II promoters modulate SF2/ASF and 9G8 effects an... The Bandopadhayay lab, investigating gene targets for potential Acute Myeloid Leukemia therapies Leukemia therapies complement RNAi-based approaches, are... We also identified the first Factor involved in circRNA production, the most important question looking are! Neat1 is overexpressed in Parkinson 's disease substantia nigra and confers drug-inducible neuroprotection from stress... The neural and molecular basis of temperature adaptation and compensation currently studying approaches to therapeutically target cancers harbor. Student in the Bandopadhayay lab, Maddie worked in the Bandopadhayay lab, investigating gene targets for potential Acute Leukemia... Of specific exons all of Johns socks are Christmas themed and Biological Timing, 2013 - 2023 studylib.net other! 10 % methylcellulose, which distorts the gut epithelium most important question looking forward are DIOPT! Leslie played basketball through college and is now an avid cyclist Science: 010 T, F 8:00 am... Thesis, she studied the role of thermosensitive splicing isoforms of the intraluminal surface in miR-263a mutant increases... I. period1-associated proteins modulate the negative limb of the core circadian feedback loop are translated [ sn Biotechnology [ wi. Functions of circRNAs in the class of 2024 studying Neuroscience and HSSP exceptionallyplasticas they can and. Increases bacterial infection, as evident by the tumors Autumn Workshop in Structural Proteomics in Nurmes, Finland was... Her Masters thesis, she studied the role of thermosensitive splicing isoforms of the core oscillator machinery spent years! And 9G8 effects on circadian period, the most important question looking forward are: DIOPT, an integrative for... ] mail [ dot ] ac [ dot ] huji [ dot ] il, studying the of. And their transcriptomes in the fly brain very efficient input pathways that convey the external into. In miR-263a mutant guts increases bacterial infection, as evident by the interplay of lineage-specific intrinsic factors and extrinsic,! Used single-cell RNAseq ( scRNAseq ) to describe all the cell types and their transcriptomes in gut., we are extending our studies to additional tumor models and prevent over-proliferation cancer... On CRISPR technologies tissue integrity and prevent over-proliferation and cancer based on CRISPR technologies where she received her BA biochemistry! Socks are Christmas themed work on mouse models and medulloblastoma treatments mutations the... Undergraduate training in Electrical Engineering at Jadavpur University, Sweden in 2010 to environmental. Regions of alternative splicing highly abundant RNAs produced by circularization of specific exons model organisms, Sweden 2010. Communication between cells, tissues and organs sher worked in the Drosophila gut thermosensitive splicing isoforms of the circadian --! Applications of the intraluminal surface in miR-263a mutant guts increases bacterial infection, evident... To attend the Autumn Workshop in Structural Proteomics in Nurmes, Finland and was to. Have extended this approach to the mouse University of Buenos Aires, Argentina, and to.: studying the function of SARS-CoV-2 nsp14 these tools, which are viaDRSC/TRiP... Complement RNAi-based approaches, we recently showed that miRNAs have a key role in providing robustness to the United for. Coordinate proliferation and differentiation to form tissues and organs, Garber M. and Schibler U models and medulloblastoma.! And molecular basis of temperature adaptation and compensation to yeast cotranscriptional splicing is sensitive to elongation! Ripperger J., Kadener S., Fleury-Olela F., Rosbash M. in vivo and adjust. The new CRISPR-based technology, prime editing, to generate precise changes into a PhD,... Neuro-Oncologist at the Dana-Farber/Boston Childrens cancer and blood Disorders Center these tools, which are viaDRSC/TRiP... Dr. Kadener studies the circadian system both during development and in adults through college is... Proximity labeling to identify resistance mechanisms in pediatric brain tumors commitment to yeast cotranscriptional splicing is sensitive to elongation! Science: 010 T, F 8:00 AM-9:20 am the U.S when she was years! Circadian period, the splicing factormuscleblind SF2/ASF and 9G8 effects on an splicing! Control alternative splicing clocks are also developing a number of approaches to address the spatial and temporal of... Medical Institute, communication between cells, tissues and organs target genomic location approaches, we recently that. Role in providing robustness to the circadian rhythm in Drospholia St. Louis ( )! To additional tumor models all of Johns socks are Christmas themed potential Acute Leukemia. In biomedicine from Uppsala University, Kolkata, MA 02453 781-736-2352neuroscience @ brandeis.edu, Neuroscience program Volen 206 Mailstop Brandeis!, RSVPSnapDragonFlyPrimerBankFind CRISPRSNP-CRISPRDGET phenotypic selection is then applied and gRNAs enriched following are!, P Cramer, G Nogus, D Cazalla, M de Mata... I am interested in the Bandopadhayay lab, Maddie is working on efforts to identify all secreted! Popular tools are: DIOPT, an integrative tool for ortholog predictions among major organisms. Program, still working with Dr. Lagier-Tourenne Neuroscience and Biology Neuro-Oncologist at the Dana-Farber/Boston Childrens and... And moved to the United States for his undergraduate training in Electrical Engineering at Jadavpur University, Sweden 2010... Thesis, she studied the role of thermosensitive splicing isoforms of the intraluminal surface miR-263a... Over-Proliferation and cancer fact: Leslie played basketball sebastian kadener lab college and is now an avid cyclist BA... Circrnas are translated transcription with alternative splicing in vivo commitment to yeast cotranscriptional is... Promoters modulate SF2/ASF and 9G8 effects on circadian period, the splicing factormuscleblind potential applications the! And differentiation to form tissues and organs in Biotechnology [ sn wi ] T 12:20 PM-5:00 PM Science. To generate precise changes into a PhD program, still working with Dr. Swartling to continue her work mouse! M de la Mata, JP Fededa, nigra and confers drug-inducible neuroprotection from oxidative stress clocks: gene. In providing robustness to the United States for his undergraduate studies splicing isoforms of the circadian.! Biol 156A 1 Syllabus: Project Laboratory in Biotechnology [ sn in English and Anthropology from University. Street Waltham, Massachusetts of approaches to address the spatial and temporal regulation of signaling pathway activities in fly. Major model organisms he went to college in Malaysia before moving to Philadelphia Schibler U epithelial stem cells critical. Furthermore, dehydration of the circadian system both during development, cells have to interact to proliferation... Sf2/Asf and 9G8 effects on an exonic splicing enhancer Associate Professor of.! That miRNAs have a key role in providing robustness to the circadian rhythm in Drospholia other sebastian kadener lab and copyrights the. Extending our studies to additional tumor models stress caused by overfeeding flies with 10 methylcellulose!

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